Hyaluronic acid has a variety of uses. Health Benefits of Hyaluronic Acid - WebMD People may be aware of the benefits of hyaluronic acid as an ingredient in skincare but may not be aware of its versatility. A study of 51 people aged 25 to 75 with laryngopharyngeal reflux (LPR) symptoms showed that HA combined with chondroitin sulfate significantly reduced LPR-related symptoms such as chronic cough and hoarseness when given with proton pump inhibitor (PPI) therapy. While it is rare to experience an allergic reaction since HA is naturally produced in your body, stop taking HA immediately and seek medical attention if you experience any signs of an allergic reaction. Clinical Rheumatology. Some research shows that pairing oral hyaluronic acid supplements with injections can help extend pain-relieving benefits and increase the amount of time between shots (26). Because Your Skin Is Already Dry One of the most fragile places on your face is the skin around your eyes. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. While HA as a dietary supplement exhibits no side effects, potential side effects may occur depending on the application method, such as an injection into the joint or topical application. In one study, experts treated people who had IC/PBS with hyaluronic acid for 3 months. 2015;22(1):55-62. doi:10.1111/srt.12228, Abdallah MM, Fernndez N, Matias AA, Bronze M do R. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Collagen supplements can help improve skin health. All rights reserved. (https://pubmed.ncbi.nlm.nih.gov/24178484/). Prescription hyaluronic acid products should be taken exactly as instructed by your healthcare provider. The 14 Best Hyaluronic Acid Serums of 2023 | by Health This article provides 11 evidence-backed benefits of using hyaluronic acid for the face and body. What is hyaluronic acid: Benefits for mature skin - CNN No serious side effects were reported in several randomized controlled trials and cohort studies when HA was given as an injection into the joint, taken by mouth, or applied topically to the skin. However, more large, high-quality studies are needed to understand the effects of oral hyaluronic acid supplements on eye health. 2022;2022:1-6. doi:10.1155/2022/6078254, Cicek N, Yildiz N, Alpay H. Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder. However, further research with large sample sizes is needed to determine the effectiveness of HA on dry eye disease. Dosage: How Much Hyaluronic Acid Should I Take? Get useful, helpful and relevant health + wellness information. This serum contains a generous 5% of four different molecular weights of pure hyaluronic acid to moisturize skin across multiple cellular levels. When the joints are lubricated, the bones are less likely to grind against each other and cause uncomfortable pain. 2020;18(3):268-277. doi:10.1111/idh.12432, Kim JS, Lee SS, Kim TJ, Park YW. Around 50% of the bodys total hyaluronic acid is present in the skin. Best Hyaluronic Acid Serums 2022 - 24 favourite formulas - Cosmopolitan We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Interstitial cystitis or painful bladder syndrome (IC/PBS) happens when your bladder walls become inflamed and irritated. 1 Benefits 2 Hyaluronic Acid 3 Luminous Pigments 4 Derm Tested. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Tolentino S, Pereira MN, Cunha-Filho M, et al. Otolaryngologia Polska. Dry . Most people can take collagen supplements, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Glucosamine supplements are popular but controversial. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study, Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study, Hyaluronic acid: a key ingredient in the therapy of inflammation, Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys, A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye, A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome, The role of oral formulation of hyaluronic acid and chondroitin sulphate for the treatment of the patients with laryngopharyngeal reflux, Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study, Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial, Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study, A randomized doubleblind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilminduced gingivitis, Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia, Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers, Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder, Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial, Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review, Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study, Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews, Effects of hyaluronic acid on bleeding following third molar extraction, Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities, Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology, Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer, Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications, Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis, Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight, Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence, Oral hyaluronan relieves knee pain: a review, Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials, Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study, Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol, A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee, Efficacy and safety of fish oil in treatment of knee osteoarthritis, The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain, Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. One 2016 study suggested that applying hyaluronic acid to the skin to heal wounds can help relieve inflammation and regulate tissue repair. If you use over-the-counter hyaluronic acid, carefully read the instructions and ingredients first. The chain has plenty of spots on it where other chemical compounds (like water, for example) can latch on. Despite the conflicting results, seek medical attention if you experience the following: Avoid hyaluronic acid derived from animal sources if you have an allergy to avian-derived products. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008, Hsu TF, Su ZR, Hsieh YH, et al. Wang SJ, Wang YH, Huang LC. Wounds. Hyaluronic acid supplements are effective at reducing joint pain in people with osteoarthritis. Unlike most serums which. All rights reserved. Its especially useful for reducing the appearance of wrinkles and age lines. Frontiers in Veterinary Science. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. While applying them directly to the eyes has been shown to reduce dry eye symptoms and improve overall eye health, it is unclear whether oral supplements have the same effects. However, these effects tend to be due to the injection itself rather than the hyaluronic acid. (https://pubmed.ncbi.nlm.nih.gov/27799626/). Journal of Medicinal Food. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Last medically reviewed on March 22, 2021, Everyone can benefit from a personalized skin care routine. Ease of Use. To understand how important moisture is for the skin, you have to first know that dehydrated skin. In a randomized, prospective study comparing the efficacy and safety of intra-articular (within the joint) HA injection and betamethasone injection in people with osteoarthritis of the thumb, people who were also being treated with anti-epileptic drugs, oral anticoagulants, lithium, potassium-sparing diuretics, digoxin, minocycline, or other medications were excluded from the study. 2021;37(9):1573-1580. doi:10.1080/03007995.2021.1950132, OHanlon CE, Newberry SJ, Booth M, et al. It's a naturally occurring compound found in high amounts within the skin, joints, and eyes. Read our, Joint Function and Pain in Osteoarthritis. 2017;10:267-273. doi:10.2147/CCID.S141845. Topical application of creams, gels, and lotions containing phytoestrogens (plant-based estrogens) for 12 to 24 weeks has increased hyaluronic acid levels. Retinol can help reduce the appearance of wrinkles, acne, cellulite, and more. This treatment works best if you have mild to moderate osteoporosis. And the last thing mature .